Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

作者: Ian D. Meng , David Julius , Sven-Eric Jordt , Diana M. Bautista , Huai-hu Chuang

DOI: 10.1038/NATURE02282

关键词:

摘要: … second messengers may excite nociceptors by targeting this member of the TRP channel family. Finally, our data suggest that ANKTM1 may also serve to excite nociceptors in response …

参考文章(28)
Peter M. Zygmunt, Jesper Petersson, David A. Andersson, Huai-hu Chuang, Morten Sørgård, Vincenzo Di Marzo, David Julius, Edward D. Högestätt, Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide Nature. ,vol. 400, pp. 452- 457 ,(1999) , 10.1038/22761
Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga, Tobias A. Rosen, Jon D. Levine, David Julius, The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature. ,vol. 389, pp. 816- 824 ,(1997) , 10.1038/39807
Peter W. Reeh, Laurence Kocher, Sigrid Jung, Does neurogenic inflammation alter the sensitivity of unmyelinated nociceptors in the rat? Brain Research. ,vol. 384, pp. 42- 50 ,(1986) , 10.1016/0006-8993(86)91217-5
G. JANCSÓ, ELISABETH KIRALY, AURELIA JANCSÓ-GÁBOR, Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones Nature. ,vol. 270, pp. 741- 743 ,(1977) , 10.1038/270741A0
Riccardo Patacchini, Carlo Alberto Maggi, Alberto Meli, None, Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 342, pp. 72- 77 ,(1990) , 10.1007/BF00178975
Fred Lembeck, Peter Holzer, Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 310, pp. 175- 183 ,(1979) , 10.1007/BF00500282
David D. McKemy, Werner M. Neuhausser, David Julius, Identification of a cold receptor reveals a general role for TRP channels in thermosensation Nature. ,vol. 416, pp. 52- 58 ,(2002) , 10.1038/NATURE719
Ruth K. Wilson, Tony K. Kwan, Chiu-Yin Kwan, George J. Sorger, Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction Life Sciences. ,vol. 71, pp. 497- 507 ,(2002) , 10.1016/S0024-3205(02)01708-3
Daniel Jaquemar, Thomas Schenker, Beat Trueb, An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. Journal of Biological Chemistry. ,vol. 274, pp. 7325- 7333 ,(1999) , 10.1074/JBC.274.11.7325
D Smart, M J Gunthorpe, J C Jerman, S Nasir, J Gray, A I Muir, J K Chambers, A D Randall, J B Davis, The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). British Journal of Pharmacology. ,vol. 129, pp. 227- 230 ,(2000) , 10.1038/SJ.BJP.0703050