Linkage of cutaneous malignant melanoma/dysplastic nevi to chromosome 9p, and evidence for genetic heterogeneity.

摘要: We examined the relationship between cutaneous malignant melanoma/dysplastic nevi (CMM/DN) and chromosome 9p in 13 pedigrees with two or more living cases of invasive melanoma. used highly informative (CA)n repeats, D9S126 IFNA, previously implicated familial melanoma (MLM), to conduct linkage analysis. Three analyses were performed: (1) CMM alone--all individuals without either confirmed borderline lesions considered unaffected (model A); (2) CMM/DN both variable age at onset sporadics B); (3) affecteds only--all designated "unknown" C). There was significant evidence for IFNA all three models. For alone, maximum lod score (Zmax) 4.36 theta = .10 model A 3.39 C. B), Zmax 3.05 .20. no alone marker D9S126. In addition, there heterogeneity when a homogeneity test allowing 1p neither region used. These results suggest that is an MLM susceptibility locus on but heterogeneous not families are linked this region.