Hypoxia inducible factor-1α and expression of vascular endothelial growth factor and its receptors in cerebral arteriovenous malformations
作者： Ivan Ng , Wan-Loo Tan , Puay-Yong Ng , Joyce Lim
DOI: 10.1016/J.JOCN.2005.02.005
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摘要: Summary Background Vascular endothelial growth factor (VEGF) and its tyrosine kinase family of receptors (VEGFR) (Flt-1, Flk-1, Flt-4) have been implicated in vascular angiogenesis remodelling cerebral arteriovenous malformations (CAVM). In this study, we investigate the role hypoxia inducible factor-1 (HIF-1α) CAVM relationship to VEGF VEGFR. Methods Surgical specimens from 26 patients undergoing resection were studied for HIF-1α , VEGF, Flt-1, Flk-1 Flt-4. The mean age was 34.08+/−14.18 years. Twenty-one presented with intracerebral haemorrhage. Results Flt-1 Flt-4 expressed all specimens. 15 patients. expression significantly associated ( p Conclusions is human CAVM. related VEGFR expression, suggesting a possible induction maintaining remodelling.
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sci-hub.se 参考文章(64)
Glyn A. S. Lloyd, Tumours of Vascular Origin Springer, London. pp. 111- 124 ,(1988) , 10.1007/978-1-4471-1629-5_11
S. V. Nicosia, R. F. Nicosia, M. Smith, Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. American Journal of Pathology. ,vol. 145, pp. 1023- 1029 ,(1994)
Lucien Jules Rubinstein, Dorothy S. Russell, Pathology of tumours of the nervous system ,(1977)
Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, Dai Fukumura, Koen Brusselmans, Mieke Dewerchin, Michal Neeman, Françoise Bono, Rinat Abramovitch, Patrick Maxwell, Cameron J. Koch, Peter Ratcliffe, Lieve Moons, Rakesh K. Jain, Désiré Collen, Eli Keshet, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. ,vol. 394, pp. 485- 490 ,(1998) , 10.1038/28867
William Feindel, Y. Lucas Yamamoto, Charles P. Hodge, Red cerebral veins and the cerebral steal syndrome. Evidence from fluorescein angiography and microregional blood flow by radioisotopes during excision of an angioma. Journal of Neurosurgery. ,vol. 35, pp. 167- 179 ,(1971) , 10.3171/JNS.1971.35.2.0167
J Stone, A Itin, T Alon, J Pe'er, H Gnessin, T Chan-Ling, E Keshet, Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia The Journal of Neuroscience. ,vol. 15, pp. 4738- 4747 ,(1995) , 10.1523/JNEUROSCI.15-07-04738.1995
Robert E. Friesel, Thomas Maciag, Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. The FASEB Journal. ,vol. 9, pp. 919- 925 ,(1995) , 10.1096/FASEBJ.9.10.7542215
Christopher W. Pugh, John F. O'Rourke, Masaya Nagao, Jonathan M. Gleadle, Peter J. Ratcliffe, Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit Journal of Biological Chemistry. ,vol. 272, pp. 11205- 11214 ,(1997) , 10.1074/JBC.272.17.11205
Tao-Sheng Li, Kimikazu Hamano, Kazuhiko Suzuki, Hiroshi Ito, Nobuya Zempo, Masunori Matsuzaki, None, Improved angiogenic potency by implantation of ex vivo hypoxia prestimulated bone marrow cells in rats. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 283, ,(2002) , 10.1152/AJPHEART.00261.2002
E. A. Pierce, R. L. Avery, E. D. Foley, L. P. Aiello, L. E. Smith, Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 905- 909 ,(1995) , 10.1073/PNAS.92.3.905