Hypoxia Response in Asthma Differential Modulation on Inflammation and Epithelial Injury
作者： Tanveer Ahmad , Manish Kumar , Ulaganathan Mabalirajan , Bijay Pattnaik , Shilpi Aggarwal
关键词: Exacerbation 、 Proinflammatory cytokine 、 Gene knockdown 、 Apoptosis 、 Asthma 、 Inflammation 、 Biology 、 Immunology 、 Pathophysiology 、 Hypoxia (medical)
摘要: … , and increased inflammatory cell infiltrate. This study shows that an exaggerated hypoxia response may contribute to airway inflammation, remodeling, and the development of asthma. …
sci-hub.se 参考文章(34)
S. Huerta-Yepez, G. J. Baay-Guzman, I. G. Bebenek, R. Hernandez-Pando, M. I. Vega, L. Chi, M. Riedl, D. Diaz-Sanchez, E. Kleerup, D. P. Tashkin, F. J. Gonzalez, B. Bonavida, M. Zeidler, O. Hankinson, Hypoxia Inducible Factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis Allergy. ,vol. 66, pp. 909- 918 ,(2011) , 10.1111/J.1398-9995.2011.02594.X
Stefanie Krick, Jörg Hänze, Bastian Eul, Rajkumar Savai, Ulrike Seay, Friedrich Grimminger, Jürgen Lohmeyer, Walter Klepetko, Werner Seeger, Frank Rose, Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1α and an autocrine angiotensin system The FASEB Journal. ,vol. 19, pp. 857- 859 ,(2005) , 10.1096/FJ.04-2890FJE
Tanveer Ahmad, Ulaganathan Mabalirajan, Kanika Hasija, Balaram Ghosh, Anurag Agrawal, None, Mepacrine treatment attenuates allergic airway remodeling segregated from airway inflammation in mice. International Immunopharmacology. ,vol. 11, pp. 74- 78 ,(2011) , 10.1016/J.INTIMP.2010.10.008
Eric METZEN, Daniel P. STIEHL, Kathrin DOEGE, Jan H. MARXSEN, Thomas HELLWIG-BÜRGEL, Wolfgang JELKMANN, Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element Biochemical Journal. ,vol. 387, pp. 711- 717 ,(2005) , 10.1042/BJ20041736
Ivan Ng, Wan-Loo Tan, Puay-Yong Ng, Joyce Lim, Hypoxia inducible factor-1α and expression of vascular endothelial growth factor and its receptors in cerebral arteriovenous malformations Journal of Clinical Neuroscience. ,vol. 12, pp. 794- 799 ,(2005) , 10.1016/J.JOCN.2005.02.005
Glenn T. Furuta, Jörn Karhausen, Sean P. Colgan, Randall S. Johnson, John E. Tomaszewski, Volker H. Haase, Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis Journal of Clinical Investigation. ,vol. 114, pp. 1098- 1106 ,(2004) , 10.1172/JCI21086
Holger K. Eltzschig, Peter Carmeliet, Hypoxia and Inflammation The New England Journal of Medicine. ,vol. 364, pp. 656- 665 ,(2011) , 10.1056/NEJMRA0910283
Andrew C.R. Epstein, Jonathan M. Gleadle, Luke A. McNeill, Kirsty S. Hewitson, John O'Rourke, David R. Mole, Mridul Mukherji, Eric Metzen, Michael I. Wilson, Anu Dhanda, Ya-Min Tian, Norma Masson, Donald L. Hamilton, Panu Jaakkola, Robert Barstead, Jonathan Hodgkin, Patrick H. Maxwell, Christopher W. Pugh, Christopher J. Schofield, Peter J. Ratcliffe, C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. ,vol. 107, pp. 43- 54 ,(2001) , 10.1016/S0092-8674(01)00507-4
T. Rangasamy, G. L. Semenza, S. N. Georas, What is hypoxia-inducible factor-1 doing in the allergic lung? Allergy. ,vol. 66, pp. 815- 817 ,(2011) , 10.1111/J.1398-9995.2011.02593.X
Hongbao Liu, Wujun Xue, Guanqun Ge, Xiaohui Luo, Yang Li, Heli Xiang, Xiaoming Ding, Puxun Tian, Xiaohui Tian, Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1α in MSCs Biochemical and Biophysical Research Communications. ,vol. 401, pp. 509- 515 ,(2010) , 10.1016/J.BBRC.2010.09.076