Hypoxia Promotes Danger-mediated Inflammation via Receptor for Advanced Glycation End Products in Cystic Fibrosis
作者： Rossana G. Iannitti , Andrea Casagrande , Antonella De Luca , Cristina Cunha , Guglielmo Sorci
DOI: 10.1164/RCCM.201305-0986OC
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摘要: Rationale: Hypoxia regulates the inflammatory-antiinflammatory balance by receptor for advanced glycation end products (RAGE), a versatile sensor of damage-associated molecular patterns. The multiligand nature RAGE places this in midst chronic inflammatory diseases.Objectives: To characterize impact hypoxia-RAGE pathway on pathogenic airway inflammation preventing effective pathogen clearance cystic fibrosis (CF) and elucidate potential role danger signal pathogenesis therapy lung inflammation.Methods: We used vivo vitro models to study hypoxia expression activity human murine CF, ligand, antimicrobial resistance fungal bacterial pneumonia.Measurements Main Results: Sustained its ligand S100B was observed epithelial cells exerted proximal promoting in...
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