The multiple faces of RAGE – opportunities for therapeutic intervention in aging and chronic disease
作者： Ravichandran Ramasamy , Alexander Shekhtman , Ann Marie Schmidt
DOI: 10.1517/14728222.2016.1111873
关键词:
摘要: Introduction: This review focuses on the multi-ligand receptor of immunoglobulin superfamily – for advanced glycation endproducts (RAGE). The accumulation multiple ligands RAGE in cellular stress milieux links to pathobiology chronic disease and natural aging.Areas covered: In this review, we present a discussion implications these ligand families disease. We recent literature role ligand–RAGE interaction consequences aging; macro- microvascular complications diabetes; obesity insulin resistance; autoimmune disorders inflammation; tumors Alzheimer’s discuss mechanisms signaling through its intracellular binding effector molecule formin DIAPH1. Physicochemical evidence how cytoplasmic domain binds FH1 (formin homology 1) DIAPH1, thereof, are also reviewed.Expert opinion: th...
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