Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats.

摘要: Exercise may alleviate locomotor impairment in Parkinson's disease (PD) or aging. Identifying molecular responses immediately engaged by exercise the nigrostriatal pathway and allied tissue reveal critical targets associated with its long-term benefits. In aging, there is loss of tyrosine hydroxylase (TH) glial cell line-derived neurotrophic factor (GDNF) receptor, GFR-α1, substantia nigra (SN). can increase GDNF expression, but effect on GFR-α1 expression unknown. Infusion into striatum SN, respectively, activity TH function SN not aged rats. also glutamate transporter which attenuates PD models. We utilized a footshock-free treadmill regimen to determine immediate impact short-term dopamine regulation, uptake 18 month old male Brown-Norway/Fischer 344 F1 hybrid significantly increased striatum. This did affect However, EAAC1 SN. These results indicate that nigral conjunction following exercise.