Use of the rat air pouch model of inflammation to evaluate regional drug delivery.
作者： D. E. Davies , A. J. Stevens , J. B. Houston
DOI: 10.1007/BF01991041
关键词:
摘要: We have used the rat inflammatory air pouch model to investigate some of pharmacokinetic and pharmacodynamic issues relating regional drug delivery. S(+)Ibuprofen was administered either intravenously or directly into at same time as irritant (carrageenan). Serial samples exudate plasma were then taken assayed for concentrations various efficacy markers. Ibuprofen given intrapouch, found inhibit in a dose-dependent manner concentration prostaglandin E2 number white cells exudate. Plasma concentration-time profiles are described s(+)Ibuprofen: there is evidence greater retention than following systemic
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