Adrenergic Regulation of Adaptive Immunity

摘要: The early hypothesis that the brain and immune system communicated with each other was first proposed from results of a study on effect taste aversion conditioning humoral responsiveness (Ader Cohen, 1975). Many studies have since confirmed existence such bidirectional regulation [reviewed in (Besedovsky Del Rey, 1996;Ader, 2000; Kohm Sanders, 2001)] provide plausible mechanisms by which alerts it is responding to an antigen, as well regulates level cell activity develops (Figure 5.1). Four key discoveries indicate exist able communicate cells peripheral system. First, primary secondary lymphoid organs are innervated sympathetic nerve fibers, signals sent activated brain. Second, neurotransmitter norepinephrine (NE) released terminals residing within parenchyma tissues after antigen or cytokine administration. Third, cells, except for Th2 express α2-adrenergic receptor (β2AR) binds NE transduce extracellular interior. And finally, lymphocyte at gene expression. Although appears regulate overall, we will focus this chapter discussion role plays regulating CD4+ T-cell B-cell activity, special emphasis placed antibody produced.