The antagonistic action of cyclic GMP and cyclic AMP on proliferation of B and T lymphocytes.

摘要: The effect of c-AMP, c-GMP and both substances together on (3H)-thymidine incorporation into nuclear DNA was investigated using spleen cells normal athymic nude mice. induces synthesis in cell populations. c-AMP inhibited the stimulatory activity as well phytohaemagglutinin (PHA) lipopolysaccharide (LPS) response cells. inhibitory PHA LPS responses can be reversed by c-GMP. possible role cyclic nucleotides regulation proliferation immune is discussed.