作者: Winfried Häuser , Frank Petzke , Lukas Radbruch , Thomas R Tölle
DOI: 10.2217/PMT.16.5
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摘要: The rise of opioid prescriptions and associated deaths ('opioid epidemic') in North America has evoked worldwide discussions on the long-term efficacy safety therapy (LtOT) for chronic noncancer pain (CNCP). We discuss if epidemic is a real or more American phenomenon. consider reasons epidemic. highlight differences appraisal evidence recent systematic reviews LtOT CNCP US European authors. similarities guidelines CNCP. point out potential indications contraindications syndromes.