Prostaglandin E2 Receptor EP2, EP3, and EP4 Agonists Inhibit Antigen-Induced Mucus Hypersecretion in the Nasal Epithelium of Sensitized Rats:
作者： Reiko Hattori , Shino Shimizu , Yuichi Majima , Takeshi Shimizu
DOI: 10.1177/000348940911800714
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摘要: Objectives:Prostaglandin (PG) E2 is a potential anti-inflammatory mediator that attenuates airway inflammation. To elucidate the functions of PGE2 receptors (EP1, EP2, EP3, and EP4) in allergic inflammation, we examined vivo effects EP agonists on mucus hypersecretion eosinophil infiltration rat nasal epithelium.Methods:We induced hypertrophic metaplastic changes goblet cells epithelium ovalbumin-sensitized rats by intranasal challenge with ovalbumin. The subcutaneous injections production were examined.Results:The EP4 agonist (1 to 100 μg/kg) dose-dependently inhibited ovalbumin-induced production. EP2 EP3 (100 also significantly antigen-induced infiltration, whereas EP1 showed no effect. This suppression was only effective when given th...
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