Goblet cell degranulation after antigen challenge in sensitized guinea pigs. Role of neutrophils.
作者： CARLOS AGUSTI , KIYOSHI TAKEYAMA , LARS OLAF CARDELL , IRIS UEKI , JAMES LAUSIER
DOI: 10.1164/AJRCCM.158.4.9801041
关键词:
摘要: Mucus hypersecretion is a common characteristic of asthma. Acute severe asthma often associated with neutrophilic infiltration into airways. Neutrophils contain elastase, potent secretagogue in Therefore, we hypothesized that instillation ovalbumin sensitized guinea pigs causes goblet cell secretion by releasing elastase from recruited neutrophils. When instilled the trachea ovalbumin-sensitized pigs, early recruitment neutrophils identified 3,3'- diaminobenzidine staining, and degranulation measured semiautomatic computer-based imaging system occurred. The Leumedin NPC 15669 (a drug inhibits leukocyte recruitment) an antibody to intercellular adhesion molecule-1 (ICAM-1) both prevented neutrophil degranulation, implicating leukocytes response. Using immunofluorescence showed after antigen challenge were CD-16-positive, Pretrea...
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