Molecular cloning of the human HAND2 gene.

作者: Mark W. Russell , Paul Kemp , Lihong Wang , Lawrence C. Brody , Seigo Izumo

DOI: 10.1016/S0167-4781(98)00237-1

关键词:

摘要: We have cloned and characterized the coding sequence of human HAND2 basic helix-loop-helix transcription factor. The amino acid includes an amino-terminal polyalanine repeat which is precisely conserved in rat gene. Northern analysis indicates that transcript 2.3 kb length strongly expressed heart.

参考文章(22)
K. Han, J.L. Manley, Functional domains of the Drosophila Engrailed protein. The EMBO Journal. ,vol. 12, pp. 2723- 2733 ,(1993) , 10.1002/J.1460-2075.1993.TB05934.X
Michael A. Rudnicki, Rudolf Jaenisch, The MyoD family of transcription factors and skeletal myogenesis BioEssays. ,vol. 17, pp. 203- 209 ,(1995) , 10.1002/BIES.950170306
S-A. Byatt, E. Baker, R. I. Richards, C. Roberts, A. Smith, Unbalanced t(4;11)(q32;q23) in a 34-year-old man with manifestations of distal monosomy 11q and trisomy 4q syndromes. American Journal of Medical Genetics. ,vol. 70, pp. 357- 360 ,(1997) , 10.1002/(SICI)1096-8628(19970627)70:4<357::AID-AJMG5>3.0.CO;2-Q
Rainer B. Lanz, Stefan Wieland, Martin Hug, Sandro Rusconi, A transcriptional repressor obtained by alternative translation of a trinucleotide repeat Nucleic Acids Research. ,vol. 23, pp. 138- 145 ,(1995) , 10.1093/NAR/23.1.138
Zvi Borochowitz, Stavit A. Shalev, Irit Yehudai, Hanna Bar-El, Hanna Dar, Emanuel Tirosh, Deletion (4)(q33—>qter): A Case Report and Review of the Literature Journal of Child Neurology. ,vol. 12, pp. 335- 337 ,(1997) , 10.1177/088307389701200510
Peter Cserjesi, Doris Brown, Gary E. Lyons, Eric N. Olson, Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Developmental Biology. ,vol. 170, pp. 664- 678 ,(1995) , 10.1006/DBIO.1995.1245
Anthony B. Firulli, David G. McFadden, Qing Lin, Deepak Srivastava, Eric N. Olson, Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1 Nature Genetics. ,vol. 18, pp. 266- 270 ,(1998) , 10.1038/NG0398-266
Y. Muragaki, S. Mundlos, J. Upton, B. R. Olsen, Altered Growth and Branching Patterns in Synpolydactyly Caused by Mutations in HOXD13 Science. ,vol. 272, pp. 548- 551 ,(1996) , 10.1126/SCIENCE.272.5261.548
Pual Riley, Lynn Anaon-Cartwight, James C. Cross, The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nature Genetics. ,vol. 18, pp. 271- 275 ,(1998) , 10.1038/NG0398-271