Distinct Sets of Genetic Alterations in Melanoma

摘要: Background Exposure to ultraviolet light is a major causative factor in melanoma, although the relationship between risk and exposure complex. We hypothesized that clinical heterogeneity explained by genetically distinct types of melanoma with different susceptibility light. Methods compared genome-wide alterations number copies DNA mutational status BRAF N-RAS 126 melanomas from four groups which degree differs: 30 skin chronic sun-induced damage 40 without such damage; 36 palms, soles, subungual (acral) sites; 20 mucosal melanomas. Results found significant differences frequencies regional changes mutation among Samples could be correctly classified into 70 percent accuracy on basis of...