Interaction of the neu/p185 and EGF receptor tyrosine kinases: Implications for cellular transformation and tumor therapy

摘要: Growth factor receptors such as the epidermal growth receptor (EGFR) and p185c-neu protein serve vital roles in transduction of differentiation, developmental, or mitogenic signaling within normal cells. Two methods analysis suggest that inappropriately high expression either tyrosine kinase promotes malignant transformation. First, data from vitro experiments indicate overexpression EGFR (or human homolog c-erbB-2) transforms cell-lines. Second, primary tumors tumor cell-lines derived many epithelial tissues (breast, stomach, ovary, pancreas) show gene amplification elevated levels. The physical functional interaction leads to formation a highly active, heterodimeric complex which synergistically activates cellular Anti-receptor antibodies have shown potential utility for down modulation these cell-surface proteins suppression phenotype. Design organic antibody “mimetics” based on structure antireceptor may provide useful therapies biological reagents affect function.