作者: D. F. Stern , M. P. Kamps
DOI: 10.1002/J.1460-2075.1988.TB02906.X
关键词:
摘要: p185neu is a receptor-like protein encoded by the neu/erbB-2 proto-oncogene. This closely related to epidermal growth factor (EGF) receptor, but does not bind EGF. We report here that incubation of Rat-1 cells with EGF stimulates tyrosine phosphorylation p185. effect specific since neither platelet derived (PDGF) nor insulin, which also receptors ligand-stimulated kinase activity, induced The EGF-stimulated p185 and receptor occurred similar kinetics dose-responses, both phosphorylations were prevented down-regulation Since EGF, these results suggested substrate for kinase. Incubation before lysis stimulated in immune complexes. acting through can regulate intrinsic activity