Characteristics of the Epidermal Growth Factor Receptor
作者： J. Boonstra , L. H. K. Defize , P. M. P. van Bergen en Henegouwen , S. W. de Laat , A. J. Verkleij
DOI: 10.1007/978-3-642-74200-2_14
关键词:
摘要: Polypeptide growth factors have been recognized as important determinants in the regulation of cellular proliferation and differentiation (Carpenter Cohen, 1979; de Laat et al., 1983; Schlessinger al. , 1983). As such these are believed to play a crucial role embryonal development on one hand carcinogenesis other (Gospodarowicz, 1981; Sporn Roberts, 1985; Thornburn Burgess, 1986; Heldin 1987). This notion is strongly supported by findings that products certain oncogenes significant homology either or their receptors (Doolittle Downward 1984; Westermark, 1984). The wide interest mechanisms action has resulted detailed knowledge molecular properties both receptors, while addition many details known about effects target cells Gospodarowicz, Moolenaar, Schlessinger, 1988; Carpenter, 1983, Nevertheless, precise nature mechanism still unknown.
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