Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.
作者： C. R. King , I. Borrello , F. Bellot , P. Comoglio , J. Schlessinger
DOI: 10.1002/J.1460-2075.1988.TB02991.X
关键词:
摘要: The epidermal growth factor receptor (EGF-R) and the erbB-2 proto-oncogene product protein are closely related by their structural homology shared enzymatic activity as autophosphorylating tyrosine kinases. We show that in mammary tumor cells (SK-BR-3) EGF causes a rapid increase phosphorylation of protein. Phosphorylation does not occur lacking EGF-R (MDA-MB-453). SK-BR-3 is blocked if prevented from interacting with its specific monoclonal antibodies. While induces down-regulation cells, has no effect on stability This result suggests substrate indicates possibility communication between these two proteins early signal transduction process.
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