Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia.

作者: Fatma Nur Kaya , Belgin Yavascaoglu , Gurkan Turker , Arzu Yildirim , Alp Gurbet

DOI: 10.1007/S12630-009-9231-6

关键词:

摘要: Purpose Midazolam has only sedative properties. However, dexmedetomidine both analgesic and properties that may prolong the duration of sensory motor block obtained with spinal anesthesia. This study was designed to compare intravenous midazolam placebo on duration, analgesia, sedation in patients undergoing transurethral resection prostate.

参考文章(24)
K. M. Ho, H. Ismail, Use of intrathecal midazolam to improve perioperative analgesia: a meta-analysis. Anaesthesia and Intensive Care. ,vol. 36, pp. 365- 373 ,(2008) , 10.1177/0310057X0803600307
David Niv, Shaul Davidovich, Eran Geller, Gideon Urca, Analgesic and hyperalgesic effects of midazolam: dependence on route of administration. Anesthesia & Analgesia. ,vol. 67, pp. 1169- 1173 ,(1988) , 10.1213/00000539-198812000-00010
Judith E. Hall, Toni D. Uhrich, Jill A. Barney, Shahbaz R. Arain, Thomas J. Ebert, Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesthesia & Analgesia. ,vol. 90, pp. 699- 705 ,(2000) , 10.1097/00000539-200003000-00035
Stuart A Grant, Dara S Breslin, David B MacLeod, David Gleason, Gavin Martin, Dexmedetomidine infusion for sedation during fiberoptic intubation: a report of three cases. Journal of Clinical Anesthesia. ,vol. 16, pp. 124- 126 ,(2004) , 10.1016/J.JCLINANE.2003.05.010
M. A. E. Ramsay, T. M. Savege, B. R. J. Simpson, R. Goodwin, Controlled sedation with alphaxalone-alphadolone BMJ. ,vol. 2, pp. 656- 659 ,(1974) , 10.1136/BMJ.2.5920.656
Dilek Karaaslan, Tulay Tuncer Peker, Adnan Alaca, Sadik Ozmen, Pakize Kirdemir, Huseyin Yorgancigil, Metin Lutfi Baydar, Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery. Journal of Clinical Anesthesia. ,vol. 18, pp. 589- 593 ,(2006) , 10.1016/J.JCLINANE.2006.03.019
Marja-Leena Jaakola, Markku Salonen, Risto Lehtinen, Harry Scheinin, The analgesic action of dexmedetomidine — a novel α2-adrenoceptor agonist — in healthy volunteers Pain. ,vol. 46, pp. 281- 285 ,(1991) , 10.1016/0304-3959(91)90111-A
K. OTA, A. NAMIKI, H. IWASAKI, I. TAKAHASI, Dose-related prolongation of tetracaine spinal anesthesia by oral clonidine in humans. Anesthesia & Analgesia. ,vol. 79, pp. 1121- 1125 ,(1994) , 10.1097/00132586-199506000-00032
Jorge A. Calasans-Maia, Gisele Zapata-Sudo, Roberto T. Sudo, Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs. Journal of Pharmacy and Pharmacology. ,vol. 57, pp. 1415- 1420 ,(2010) , 10.1211/JPP.57.11.0006