Recent Advances, Challenges, and Opportunities in Riboswitches

摘要: Riboswitch is a regulatory element of the mRNA, binds small molecule, and modulates translation process synthesizing corresponding protein. Hence, RNA capable with self-regulation. This an important mechanism transcription posttranscription level gene regulations in central dogma. has conserved motif present 5′ UTRs, upstream region genes. In this chapter, we have provided detailed information on riboswitches up-to-date scientific findings design applications synthetic industry medicine domains. review, unique molecular features such as ligand-binding, termination-regulating, translational-regulating properties are also discussed. Besides many experimental techniques, nonredundant role computational techniques emphasized. Additionally, stability conformational dynamics their biophysical models explaining ligand-binding initiation rate highlighted.