Vitamin D status in children, adolescents, and young adults with Crohn disease

摘要: BACKGROUND Crohn disease (CD) and vitamin D deficiency are associated with decreased bone mineralization. OBJECTIVE We examined the prevalence of risk factors for hypovitaminosis in children, adolescents, young adults CD. DESIGN Growth, clinical characteristics, intake ( micro g/d), mineral density (g/cm(2)) were measured a cross-sectional study 112 subjects (44 females) who had CD 5-22 y age. Hypovitaminosis was defined as serum concentration 25-hydroxyvitamin [25(OH)D] < 38 nmol/L. RESULTS The mean (+/- SD) 25(OH)D 59.7 +/- 26.9 nmol/L, 16% (95% CI: 9.3%, 23%) D. most prevalent during winter (31%; P = 0.02), among African Americans (56%; 0.01), confined to upper gastrointestinal tract (44%; 0.05), greater lifetime exposure glucocorticoid therapy (23.7 13.5 compared 17.5 12.2 mg/d; 0.05). There no association between either (P 0.10) or average dietary (4.6 3.6 g/d; 0.87). CONCLUSIONS In this sample pediatric patients CD, common season, American ethnicity, tract, magnitude therapy. occurrence these should prompt assessment status care optimized by supplementing have low concentrations. physiologic relevance ethnicity on children remains be determined.