Proteases Produced by Vibrio cholerae and Other Pathogenic Vibrios: Pathogenic Roles and Expression

摘要: Pathogenic vibrios produce various pathogenic factors such as enterotoxin, hemolysin, cytotoxin, protease, siderophore, adhesive factor, and hemagglutinin. Direct toxic cytotoxin are related to the symptoms, whereas siderophore may cause indirect factors, which play roles in establishment of infection. The proteases produced by long recognized Zn metalloprotease Vibrio cholerae is thought processing other protein toxin(s) or supporting bacterial growth digestive tract. Hemagglutinin/protease (HA/P) V. was one first noticed has 609 amino acid residues a molecular size 69.3 kDa. Further characterization this revealed that C-terminal peptide mediates hemagglutination binding cell surface many vibrios. HA/P secreted via type II secretion pathway at pole role promoting mucin gel penetration, detachment, spread infection along gastrointestinal Special interaction on chironomid egg masses shown be an important factor for survival aquatic environments. Vibrios have complex quorum-sensing system containing three kinds autoinducers. In some, plays controlling machinery. A cysteine protease domain found repeat toxin (RTX) cholerae. RTX large multifunctional causes actin cross-linking processed proteolytic action during translocation into host cells. Other vulnificus (VVP) well known damage association with major virulence. Thus, variety pathological roles.