Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery.
作者： D Caillot , O Casasnovas , A Bernard , J F Couaillier , C Durand
DOI: 10.1200/JCO.1997.15.1.139
关键词:
摘要: PURPOSEThe prognosis of invasive pulmonary aspergillosis (IPA) occurring in neutropenic patients remains poor. We studied whether new strategies for early diagnosis could improve outcome these patients.PATIENTS AND METHODSTwenty-three histologically proven and 14 highly probable IPAs 37 hematologic (neutropenic 36) were analyzed retrospectively.RESULTSThe most frequent clinical signs associated with IPA cough (92%), chest pain (76%), hemoptysis (54%). Bronchoalveolar lavage (BAL) was positive 22 32 cases. Aspergillus antigen test 83% cases when tested on BAL fluid. Since October 1991, thoracic computed tomographic (CT) scans systematically performed febrile x-ray infiltrates. This approach allowed us to recognize suggestive CT halo 92% patients, compared 13% before this date, the mean time reduced dramatically from 7 1.9 days. Among 36 assessable 10 f...
sci-hub.se 参考文章(35)
S M Albelda, G H Talbot, W T Miller, S L Gerson, P A Cassileth, Pulmonary cavitation and massive hemoptysis in invasive pulmonary aspergillosis. Influence of bone marrow recovery in patients with acute leukemia The American review of respiratory disease. ,vol. 131, pp. 115- 120 ,(1985) , 10.1164/ARRD.1985.131.1.115
Frederick W. Kahn, Jefffiey M. Jones, Douglas M. England, The role of bronchoalveolar lavage in the diagnosis of invasive pulmonary aspergillosis. American Journal of Clinical Pathology. ,vol. 86, pp. 518- 523 ,(1986) , 10.1093/AJCP/86.4.518
V Annaix, J P Bouchara, G Larcher, D Chabasse, G Tronchin, Specific binding of human fibrinogen fragment D to Aspergillus fumigatus conidia. Infection and Immunity. ,vol. 60, pp. 1747- 1755 ,(1992) , 10.1128/IAI.60.5.1747-1755.1992
Philippe Moreau, Jean-Ralph Zahar, Noël Milpied, Oliver Baron, Béatrice Mahé, Depei Wu, Patrick Germaud, Philippe Despins, Anne-Yvonne Delajartre, Jean-Luc Harousseau, Localized invasive pulmonary aspergillosis in patients with neutropenia. Effectiveness of surgical resection Cancer. ,vol. 72, pp. 3223- 3226 ,(1993) , 10.1002/1097-0142(19931201)72:11<3223::AID-CNCR2820721115>3.0.CO;2-R
J E Kuhlman, E K Fishman, S S Siegelman, Invasive pulmonary aspergillosis in acute leukemia: characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis. Radiology. ,vol. 157, pp. 611- 614 ,(1985) , 10.1148/RADIOLOGY.157.3.3864189
David W. Denning, Jeanette Y. Lee, John S. Hostetler, Peter Pappas, Carol A. Kauffman, Daniel H. Dewsnup, John N. Galgiani, John R. Graybill, Alan M. Sugar, Antonino Catanzaro, Harry Gallis, John R. Perfect, Bonita Dockery, William E. Dismukes, David A. Stevens, NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis The American Journal of Medicine. ,vol. 97, pp. 135- 144 ,(1994) , 10.1016/0002-9343(94)90023-X
LIVIO PAGANO, Paolo Ricci, Annamaria Nosari, Anna Tonso, Massimo Buelli, Marco Montillo, Laura Cudillo, Annarita Cenacchi, Chiara Savignana, Lorella Melillo, Anna Chierichini, Roberto Marra, Giampaolo Bucaneve, Giuseppe Leone, Albano Del Favero, , Fatal haemoptysis in pulmonary filamentous mycosis: an underevaluated cause of death in patients with acute leukaemia in haematological complete remission. A retrospective study and review of the literature British Journal of Haematology. ,vol. 89, pp. 500- 505 ,(1995) , 10.1111/J.1365-2141.1995.TB08355.X
K WONG, C WATERS, R WALESBY, Surgical management of invasive pulmonary aspergillosis in immunocompromised patients. European Journal of Cardio-Thoracic Surgery. ,vol. 6, pp. 138- 143 ,(1992) , 10.1016/1010-7940(92)90119-I
David W. Denning, David A. Stevens, Antifungal and Surgical Treatment of Invasive Aspergillosis: Review of 2,121 Published Cases Clinical Infectious Diseases. ,vol. 12, pp. 1147- 1201 ,(1990) , 10.1093/CLINIDS/12.6.1147
Ulrich Blum, Marisa Windfuhr, Carlos Buitrago-Tellez, Günther Sigmund, Eberhard W. Herbst, Mathias Langer, Invasive Pulmonary Aspergillosis Chest. ,vol. 106, pp. 1156- 1161 ,(1994) , 10.1378/CHEST.106.4.1156