Studies on Inhibition of Proliferation of Enterovirus-71 by Compound YZ-LY-0.

摘要: In recent years, hand-foot-and-mouth disease (HFMD), which is caused by Enteroviruses, has emerged as a serious illness. It affects mainly children under the age of five and results in high fatality rates. Enterovirus 71 (EV71) main causative agent HFMD China currently there are no effective anti-viral drugs available to treat HFMD. present study, we screened compounds for inhibition proliferation EV71. Compound YZ-LY-0 stalled life cycle The inhibitor exhibited EC50 value 0.29 μm against SK-EV006 strain Notably, had low cytotoxicity (CC50 > 100 μM) selectivity index (over 300) Vero RD cells. combination with an EV71 RdRp or entry showed antagonistic effect at very concentrations. However, higher concentrations inhibitors synergistic inhibiting viral replication. Preliminary on investigation mechanism indicate that does not block virus host cell, but instead inhibits early stage Our studies provide potential clinical therapeutic option infections suggest combined application other could be more treatment