Optogenetics: the new molecular approach to control functions of neural cells in epilepsy, depression and tumors of the central nervous system.
作者： Paulo Henrique Pires de Aguiar , Manoela Marques Ortega , Bruno Camporeze , Carlos Tadeu Parisi de Oliveira , Luis Roberto Mathias Junior
DOI:
关键词:
摘要: The optogenetic tools have been described as valuable techniques to study neural activity through light stimulation, well potential neuromodulator approaches in the management of several central nervous system (CNS) diseases. Since first bacteriorhodopsin protein a single-component light-activated regulator transmembrane ion flow description, 1980's, focus has on channel proteins for neurobiology; however, advances engineering showed involvement changes cellular biological behavior types involved cell cytoskeleton regulation, motility and gene expression. Although use this technology published many papers, question still remains regarding real results clinical applicability CNS diseases, publications scarcity that systematically analyses results. Lastly, aim review is discuss experimental results, molecular mechanisms applications epilepsy depression treatment, its treatment tumors.
参考文章(115)
Viviana Gradinaru, Kimberly R. Thompson, Karl Deisseroth, eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications Brain Cell Biology. ,vol. 36, pp. 129- 139 ,(2008) , 10.1007/S11068-008-9027-6
Rosemary C Bagot, Benoit Labonté, Catherine J Peña, Eric J Nestler, Epigenetic signaling in psychiatric disorders: stress and depression. Dialogues in clinical neuroscience. ,vol. 16, pp. 281- 295 ,(2014) , 10.31887/DCNS.2014.16.3/RBAGOT
Ofer Yizhar, Lief Fenno, Feng Zhang, Peter Hegemann, Karl Diesseroth, Microbial Opsins: A Family of Single-Component Tools for Optical Control of Neural Activity CSH Protocols. ,vol. 2011, ,(2011) , 10.1101/PDB.TOP102
Wayne C. Drevets, Joseph L. Price, Maura L. Furey, Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression Brain Structure & Function. ,vol. 213, pp. 93- 118 ,(2008) , 10.1007/S00429-008-0189-X
R. C. Wykes, J. H. Heeroma, L. Mantoan, K. Zheng, D. C. MacDonald, K. Deisseroth, K. S. Hashemi, M. C. Walker, S. Schorge, D. M. Kullmann, Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy Science Translational Medicine. ,vol. 4, pp. 3004190- ,(2012) , 10.1126/SCITRANSLMED.3004190
Michael Grusch, Karin Schelch, Robert Riedler, Eva Reichhart, Christopher Differ, Walter Berger, Álvaro Inglés‐Prieto, Harald Janovjak, Spatio‐temporally precise activation of engineered receptor tyrosine kinases by light The EMBO Journal. ,vol. 33, pp. 1713- 1726 ,(2014) , 10.15252/EMBJ.201387695
Mark H. Histed, Vincent Bonin, R. Clay Reid, Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation Neuron. ,vol. 63, pp. 508- 522 ,(2009) , 10.1016/J.NEURON.2009.07.016
Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Doreen Koretz, Kathleen R Merikangas, A John Rush, Ellen E Walters, Philip S Wang, None, The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. ,vol. 289, pp. 3095- 3105 ,(2003) , 10.1001/JAMA.289.23.3095
S. H. Elsea, R. E. Lucas, The Mousetrap: What We Can Learn When the Mouse Model Does Not Mimic the Human Disease Ilar Journal. ,vol. 43, pp. 66- 79 ,(2002) , 10.1093/ILAR.43.2.66
Jiayi Zhang, Farah Laiwalla, Jennifer A Kim, Hayato Urabe, Rick Van Wagenen, Yoon-Kyu Song, Barry W Connors, Feng Zhang, Karl Deisseroth, Arto V Nurmikko, Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue Journal of Neural Engineering. ,vol. 6, pp. 055007- 055007 ,(2009) , 10.1088/1741-2560/6/5/055007