Analytical methods for trace levels of reactive carbonyl compounds formed in lipid peroxidation systems.

作者: T. Shibamoto

DOI: 10.1016/J.JPBA.2006.01.047

关键词:

摘要: Analysis of trace levels reactive carbonyl compounds (RCCs), including formaldehyde, acetaldehyde, acrolein, malonaldehyde, glyoxal, and methyl is extremely difficult because they are highly reactive, water soluble, volatile. Determination these RCCs in important major products lipid peroxidation, which strongly associated with various diseases such as cancer, Alzheimer's disease, aging, atherosclerosis. This review covers the development application derivatives for RCC analysis. Among many have been prepared, cysteamine formaldehyde acetaldehyde; N-hydrazine 4-hydroxy-2-nonenal, malonaldeyde; o-phenylene diamine glyoxal were selected extended discussion. The advanced instruments, gas chromatograph nitrogen-phosphorus detector (GC/NPD), mass spectrometer (MS), high performance liquid (HPLC), GC/MS, LC/MS, to determination oxidized samples, fatty acids, skin lipids, beef fats, blood plasma, whole blood, liver homogenates, also discussed.

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