DNA Methylation Patterns in the Early Human Embryo and the Epigenetic/Imprinting Problems: A Plea for a More Careful Approach to Human Assisted Reproductive Technology (ART).

摘要: An increasing number of publications indicate that babies born after IVF (in vitro fertilization) procedures have higher rates anomalies related to imprinting/epigenetic changes, which may be attributed suboptimal culture conditions. Appropriate maintenance DNA methylation during the first few days an in requires a supply methyl donors, are lacking current systems. The absence protection against oxidative stress increases risks for errors methylation. A decrease processes is sometimes observed immediately post fertilization, due delays occur maternal–zygotic transition period. Care should exercised ART (assisted reproductive technology) order avoid risk generating period has impact on imprinting/epigenetics. Formulation media needs re-assessed perspective knowledge regarding embryo physiology.