New insights into human pre-implantation metabolism in vivo and in vitro.

摘要: The metabolism of pre-implantation embryos is far from being understood. In human embryos, the two major obstacles are scarcity material, for obvious ethical reasons, and complete absence a relevant in vivo control model. Over-extrapolation animal species to systems adds complexity problem. Removal some metabolites media has been proposed, such as glucose essential amino acids, on basis their pseudo “toxicity”. contrast, addition compounds growth factors proposed order decrease apoptosis, which natural physiologic process. These suggestions reflect global knowledge, consequence mask reality. Some aspects have ignored, lipid metabolism. Others seriously underestimated, oxidative stress its relationship imprinting/methylation, paramount importance genetic regulation chromosomal stability. It become increasingly that more studies essential, especially view extension ART activities worldwide.