Aging Does not Affect Beta-Agonist Responsiveness after Methacholine-Induced Bronchoconstriction
作者： Annie Lin Parker
DOI: 10.1111/J.1532-5415.2004.52110.X
关键词:
摘要: Objectives: To assess the response to an inhaled beta-agonist alone or in combination with anticholinergic agent after methacholine-induced bronchoconstriction four age groups. Design: Retrospective analysis. Setting: Pulmonary function laboratory a university-affiliated hospital. Participants: Seven hundred sixty-four consecutive subjects 20% reduction more forced expiratory volume during first second (FEV1) of exhalation from total lung capacity inhaling 189 fewer cumulative units methacholine were included analysis. Intervention: The 382 received three inhalations metaproterenol (total 1.95 mg), and other albuterol ipratropium 309 μg 54 μg ipratropium) bronchoconstriction. Measurements: bronchodilators was assessed as postbronchodilator percentage change FEV1 recovering 90% better baseline use bronchodilator. Results: elderly similar that younger subjects. who recovered their also groups. Response albuterol/ipratropium all groups (all P>.05). Conclusion: Aging does not affect bronchodilator bronchoconstriction. responsiveness is
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