NMR and EPR structural delineation of copper(II) complexes formed by kanamycin A in water.
作者： Nicola D′Amelio , Elena Gaggelli , Nicola Gaggelli , Elena Molteni , Maria Camilla Baratto
DOI: 10.1039/B313060F
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摘要: The complexes formed by kanamycin A at three different pH values (5.5, 7.4 and 12.0) were investigated NMR EPR spectroscopy. Paramagnetic relaxation contributions to proton rates measured using a combination of the TOCSY sequence with inversion recovery experiment in order gain signal resolution bulk region. Measured converted into distances used for structural determination restrained simulated annealing where all possible chair boat conformations rings taken account. interaction Cu(II) ion nitrogen C ring is apparent values. At higher also amino group starts be involved metal coordination sphere. This accompanied switch conformation C. Structures are consistent involvement sphere either 2' or 4' hydroxyl oxygens 5.5 5 6' (or oxygen) 12.0.
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