Coordination pattern, solution structure and DNA damage studies of the copper(II) complex with the unusual aminoglycoside antibiotic hygromycin B
作者： Elena Gaggelli , Nicola Gaggelli , Elena Molteni , Gianni Valensin , Duccio Balenci
DOI: 10.1039/C0DT00458H
关键词:
摘要: The aminoglycosidic antibiotic hygromycin B presents a peculiar chemical structure, characterized by two sugar rings joined via spiro connection. Cu(II) complex of in water solution was 1H-NMR, UV-Vis, EPR and CD spectroscopy, combined with potentiometric measurements. spin–lattice relaxation enhancements were interpreted the Solomon-Bloembergen-Morgan theory, allowing us to calculate copper-proton distances that used build model molecular mechanics dynamics calculations. fidelity proposed checked ROESY maps. Moreover DNA damage Cu(II)-hygromycin system also investigated, showing single double strand scissions exerted at concentrations range 1–5 mM. Addition either hydrogen peroxide or ascorbic acid each sample resulted shift cleavage potency towards lower complex.
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C.A.G. Haasnoot, F.A.A.M. de Leeuw, C. Altona, The relationship between proton-proton NMR coupling constants and substituent electronegativities—I : An empirical generalization of the karplus equation Tetrahedron. ,vol. 36, pp. 2783- 2792 ,(1980) , 10.1016/0040-4020(80)80155-4
Małgorzata Jeżowska-Bojczuk, Wojciech Szczepanik, Wojciech Leśniak, Jerzy Ciesiołka, Jan Wrzesiński, Wojciech Bal, DNA and RNA damage by Cu(II)-amikacin complex. FEBS Journal. ,vol. 269, pp. 5547- 5556 ,(2002) , 10.1046/J.1432-1033.2002.03260.X
Nicola D′Amelio, Elena Gaggelli, Nicola Gaggelli, Elena Molteni, Maria Camilla Baratto, Gianni Valensin, Malgorzata Jezowska-Bojczuk, Wojciech Szczepanik, NMR and EPR structural delineation of copper(II) complexes formed by kanamycin A in water. Dalton Transactions. pp. 363- 368 ,(2004) , 10.1039/B313060F
M. W. Whitehouse, Ambivalent role of copper in inflammatory disorders Inflammation Research. ,vol. 6, pp. 201- 206 ,(1976) , 10.1007/BF01972209
Felix Freire, Igor Cuesta, Francisco Corzana, Julia Revuelta, Carlos González, Milos Hricovini, Agatha Bastida, Jesús Jiménez-Barbero, Juan Luis Asensio, A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer Chemical Communications. ,vol. 2, pp. 174- 176 ,(2007) , 10.1039/B611597G
Wojciech Szczepanik, Ewa Dworniczek, Jerzy Ciesiołka, Jan Wrzesiński, Jacek Skała, Małgorzata Jeżowska-Bojczuk, In vitro oxidative activity of cupric complexes of kanamycin A in comparison to in vivo bactericidal efficacy. Journal of Inorganic Biochemistry. ,vol. 94, pp. 355- 364 ,(2003) , 10.1016/S0162-0134(03)00029-1
Alan J. Lewis, The role of copper in inflammatory disorders Inflammation Research. ,vol. 15, pp. 513- 519 ,(1984) , 10.1007/BF01966765
Wojciech Szczepanik, Magdalena Świątek, Jacek Skała, Małgorzata Jeżowska-Bojczuk, ATP, histidine or magnesium ions can protect DNA against sisomicin-induced damage, following stray Cu(II) binding Archives of Biochemistry and Biophysics. ,vol. 431, pp. 88- 94 ,(2004) , 10.1016/J.ABB.2004.07.018
E. Ämmälahti, M. Bardet, D. Molko, J. Cadet, Evaluation of Distances from ROESY Experiments with the Intensity-Ratio Method Journal of Magnetic Resonance, Series A. ,vol. 122, pp. 230- 232 ,(1996) , 10.1006/JMRA.1996.0199
I. Solomon, Relaxation Processes in a System of Two Spins Physical Review. ,vol. 99, pp. 559- 565 ,(1955) , 10.1103/PHYSREV.99.559