Femoral Neck BMD Is a Strong Predictor of Hip Fracture Susceptibility in Elderly Men and Women Because It Detects Cortical Bone Instability: The Rotterdam Study

摘要: We studied HSA measurements in relation to hip fracture risk 4806 individuals (2740 women). Hip fractures (n = 147) occurred at the same absolute levels of bone instability both sexes. Cortical (propensity thinner cortices wide diameters buckle) explains why different BMD is across sexes. Introduction: Despite sexual dimorphism bone, very similar men and women BMD. aimed elucidate main structural properties that underlie measured ultimately determines elderly women. Materials Methods: This study part Rotterdam Study (a large prospective population-based cohort) included 147 incident cases participants with DXA-derived analysis (mean follow-up, 8.6 yr). Indices compared neck width, cortical thickness, section modulus (an index bending strength), buckling ratio instability). used a mathematical model calculate distribution by femoral BMD, BMC, area, structure (HSA) parameters (cortical narrow ratio) it data from Study. Results: In data, sexes had lower cortices, greater strength, higher baseline. fractured individuals, an average was 0.09 g/cm2 than (p < 0.00001), whereas no significant difference ratios seen. Modeled were concordance showed seem occur (buckling women. No differences observed between areas under ROC curves (0.8146 0.8048 men) (0.8161 0.7759 men). Conclusions: The instability) portrays critical balance thickness width. Our findings suggest extreme thinning expanded bones plays key role on local susceptibility fracture. Even though does not offer additional predictive value, these improve our understanding low good predictor fragility fractures.