Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis
作者： V. Deretic , Michael J. Schurr , Hongwei Yu
DOI: 10.1016/S0966-842X(00)88974-X
关键词:
摘要: During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence. The mutations underlying these changes occur global regulators, such as alternative sigma factors and their accessory elements.
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