Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases

摘要: Mucins are major glycoprotein components of the mucus that coats surfaces cells lining respiratory, digestive, gastrointestinal and urogenital tracts. They function to protect epithelial from infection, dehydration physical or chemical injury, as well aid passage materials through a tract i.e., lubrication. also implicated in pathogenesis benign malignant diseases secretory cells. In Human there two types mucins, membrane-bound secreted originated mucous producing goblet localized cell layer glands encoded by MUC gene. belong heterogeneous family high molecular weight proteins composed long peptidic chain with large number tandem repeats form so-called mucin domain. The is generally high, ranging between 0.2 10 million Dalton all mucins contain one more domains which highly glycosylated. size vary genetic polymorphism represents (VNTR polymorphisms), means individual can differ substantially individuals be used markers. human it only MUC1 MUC7 have less than 40% serine threonine turn could reduce PTS domains. considered powerful two-edged sword, its normal protects unwanted substances organisms at an arm's length while, malfunction may important factor diseases. this review we unearthed current status different understanding role various non-communicable special reference organ specific locations. findings described direct relevance research area biomedicine associated