Intestinal microbiota and type 2 diabetes: From mechanism insights to therapeutic perspective
作者： Jun-Ling Han , Hui-Ling Lin
DOI: 10.3748/WJG.V20.I47.17737
关键词:
摘要: The incidence of type 2 diabetes (T2DM) is rapidly increasing worldwide. However, the pathogenesis T2DM has not yet been well explained. Recent evidence suggests that intestinal microbiota composition associated with obesity and T2DM. In this review, we provide an overview about mechanisms underlying role in There clear influences host through its effect on body weight, bile acid metabolism, proinflammatory activity insulin resistance, modulation gut hormones. Modulating use probiotics, prebiotics, antibiotics, fecal transplantation may have benefits for improvement glucose metabolism resistance host. Further studies are required to increase our understanding complex interplay between be able boost development new effective therapeutic approaches
sci-hub.se 参考文章(80)
B. V. Jones, M. Begley, C. Hill, C. G. M. Gahan, J. R. Marchesi, Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 13580- 13585 ,(2008) , 10.1073/PNAS.0804437105
Julie Amyot, Meriem Semache, Mourad Ferdaoussi, Ghislaine Fontés, Vincent Poitout, Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling PLoS ONE. ,vol. 7, pp. e36200- ,(2012) , 10.1371/JOURNAL.PONE.0036200
M. Aguilera, P. Vergara, V. Martínez, Stress and antibiotics alter luminal and wall-adhered microbiota and enhance the local expression of visceral sensory-related systems in mice Neurogastroenterology and Motility. ,vol. 25, ,(2013) , 10.1111/NMO.12154
Anne Vrieze, Els Van Nood, Frits Holleman, Jarkko Salojärvi, Ruud S. Kootte, Joep F.W.M. Bartelsman, Geesje M. Dallinga–Thie, Mariette T. Ackermans, Mireille J. Serlie, Raish Oozeer, Muriel Derrien, Anne Druesne, Johan E.T. Van Hylckama Vlieg, Vincent W. Bloks, Albert K. Groen, Hans G.H.J. Heilig, Erwin G. Zoetendal, Erik S. Stroes, Willem M. de Vos, Joost B.L. Hoekstra, Max Nieuwdorp, Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome Gastroenterology. ,vol. 143, pp. 913- 916 ,(2012) , 10.1053/J.GASTRO.2012.06.031
June Zhou, Roy J. Martin, Richard T. Tulley, Anne M. Raggio, Kathleen L. McCutcheon, Li Shen, Samuel Colby Danna, Sasmita Tripathy, Maren Hegsted, Michael J. Keenan, Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents American Journal of Physiology-endocrinology and Metabolism. ,vol. 295, ,(2008) , 10.1152/AJPENDO.90637.2008
Nathalie Esser, Sylvie Legrand-Poels, Jacques Piette, André J. Scheen, Nicolas Paquot, Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes Diabetes Research and Clinical Practice. ,vol. 105, pp. 141- 150 ,(2014) , 10.1016/J.DIABRES.2014.04.006
A Alisi, G Bedogni, G Baviera, V Giorgio, E Porro, C Paris, P Giammaria, L Reali, Frank Anania, V Nobili, None, Randomised clinical trial: The beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis. Alimentary Pharmacology & Therapeutics. ,vol. 39, pp. 1276- 1285 ,(2014) , 10.1111/APT.12758
Junjie Qin, Yingrui Li, Zhiming Cai, Shenghui Li, Jianfeng Zhu, Fan Zhang, Suisha Liang, Wenwei Zhang, Yuanlin Guan, Dongqian Shen, Yangqing Peng, Dongya Zhang, Zhuye Jie, Wenxian Wu, Youwen Qin, Wenbin Xue, Junhua Li, Lingchuan Han, Donghui Lu, Peixian Wu, Yali Dai, Xiaojuan Sun, Zesong Li, Aifa Tang, Shilong Zhong, Xiaoping Li, Weineng Chen, Ran Xu, Mingbang Wang, Qiang Feng, Meihua Gong, Jing Yu, Yanyan Zhang, Ming Zhang, Torben Hansen, Gaston Sanchez, Jeroen Raes, Gwen Falony, Shujiro Okuda, Mathieu Almeida, Emmanuelle LeChatelier, Pierre Renault, Nicolas Pons, Jean-Michel Batto, Zhaoxi Zhang, Hua Chen, Ruifu Yang, Weimou Zheng, Songgang Li, Huanming Yang, Jian Wang, S Dusko Ehrlich, Rasmus Nielsen, Oluf Pedersen, Karsten Kristiansen, Jun Wang, None, A metagenome-wide association study of gut microbiota in type 2 diabetes Nature. ,vol. 490, pp. 55- 60 ,(2012) , 10.1038/NATURE11450
Ruth E. Ley, Peter J. Turnbaugh, Samuel Klein, Jeffrey I. Gordon, Microbial ecology: Human gut microbes associated with obesity Nature. ,vol. 444, pp. 1022- 1023 ,(2006) , 10.1038/4441022A
Francisco Javier Bermudez-Silva, Irene Sanchez-Vera, Juan Suárez, Antonia Serrano, Esther Fuentes, Pablo Juan-Pico, Angel Nadal, Fernando Rodríguez de Fonseca, Role of cannabinoid CB2 receptors in glucose homeostasis in rats European Journal of Pharmacology. ,vol. 565, pp. 207- 211 ,(2007) , 10.1016/J.EJPHAR.2007.02.066