2- and 3-Stage temperature ramping for the direct synthesis of adipic acid in micro-flow packed-bed reactors

摘要: The synthesis of adipic acid from cyclohexene and hydrogen peroxide was investigated in micro-flow packed-bed reactors. isolated yield increases with increasing residence time addition phosphoric cannot effectively improve the though it is generally known to reduce decomposition H2O2. Then, different temperatures were tested along reactor length, since consist 6 elementary reactions temperature needs. For experiments 2-stage ramping, 70 °C 100 °C, respectively, are optimal for first stage second reactor, which lead 63% acid. Furthermore, 3-stage ramping improves 66%. Multi-injection at stages does not a further increase yield. Although high used this transformation, in-line recording profiles flow axis shows that safe operation exothermic reaction can be realized Notably, space–time yields reactors more than one order magnitude higher those obtained batch