Recent advances in the development of a chemically synthesised anti-malarial vaccine
作者： Hernando Curtidor , Manuel E Patarroyo , Manuel A Patarroyo , None
DOI: 10.1517/14712598.2015.1075505
关键词:
摘要: Introduction: Obtaining an effective antimalarial vaccine has represented one of the biggest public health challenges over last 50 years. Despite efforts by many laboratories around world using whole-organism, recombinant proteins and genome-based approaches, results have been disappointing. One main problems when designing is poor immunogenicity induced functionally relevant conserved protein regions parasite.Areas covered: This review focuses on logical rational methodology followed to identify Plasmodium falciparum functional with ability bind target cells high activity binding peptides (cHABPs) physicochemical immunological characteristics that should be taken into account for modifying them highly immunogenic protection-inducing (mHABPs) in Aotus monkeys.Expert opinion: The approach develop a fu...
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