作者: Peter Bauer , Meinhard Kieser
DOI: 10.1002/(SICI)1097-0258(19990730)18:14<1833::AID-SIM221>3.0.CO;2-3
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摘要: … integration of both steps in a single con"rmatory trial and thus allows combination of di!erent phases in the development of medical treatments. Basically, the probability of erroneously …