Combining different phases in the development of medical treatments within a single trial

作者: Peter Bauer , Meinhard Kieser

DOI: 10.1002/(SICI)1097-0258(19990730)18:14<1833::AID-SIM221>3.0.CO;2-3

关键词:

摘要: … integration of both steps in a single con"rmatory trial and thus allows combination of di!erent phases in the development of medical treatments. Basically, the probability of erroneously …

参考文章(23)
Michael D. Hughes, Stopping guidelines for clinical trials with multiple treatments Statistics in Medicine. ,vol. 12, pp. 901- 915 ,(1993) , 10.1002/SIM.4780121002
D. Siegmund, A sequential clinical trial for comparing three treatments Annals of Statistics. ,vol. 21, pp. 464- 483 ,(1993) , 10.1214/AOS/1176349037
D. J. BARTHOLOMEW, A TEST OF HOMOGENEITY FOR ORDERED ALTERNATIVES. II Biometrika. ,vol. 46, pp. 328- 335 ,(1959) , 10.1093/BIOMET/46.3-4.328
P. Bauer, J. Röhmel, An adaptive method for establishing a dose‐response relationship Statistics in Medicine. ,vol. 14, pp. 1595- 1607 ,(1995) , 10.1002/SIM.4780141410
Charles W. Dunnett, A Multiple Comparison Procedure for Comparing Several Treatments with a Control Journal of the American Statistical Association. ,vol. 50, pp. 1096- 1121 ,(1955) , 10.1080/01621459.1955.10501294
Jason C. Hsu, Donald G. Edwards, Sequential Multiple Comparisons with the Best Journal of the American Statistical Association. ,vol. 78, pp. 958- 964 ,(1983) , 10.1080/01621459.1983.10477046
Constantinos Goutis, George Casella, Martin T. Wells, Assessing Evidence in Multiple Hypotheses Journal of the American Statistical Association. ,vol. 91, pp. 1268- 1277 ,(1996) , 10.1080/01621459.1996.10476996
M. Bauer, P. Bauer, M. Budde, A simulation program for adaptive two stage designs Computational Statistics & Data Analysis. ,vol. 26, pp. 351- 371 ,(1998) , 10.1016/S0167-9473(97)00034-0
Rebecca A. Betensky, An O'Brien-Fleming sequential trial for comparing three treatments Annals of Statistics. ,vol. 24, pp. 1765- 1791 ,(1996) , 10.1214/AOS/1032298294