Injection moulded controlled release amorphous solid dispersions: Synchronized drug and polymer release for robust performance

摘要: A study has been carried out to investigate controlled release performance of caplet shaped injection moulded (IM) amorphous solid dispersion (ASD) tablets based on the model drug AZD0837 and polyethylene oxide (PEO). The physical/chemical storage stability robustness IM were characterized compared that conventional extended (ER) hydrophilic matrix same raw materials compositions manufactured via direct compression (DC). To gain an improved understanding mechanisms, dissolution both polymer studied. Under conditions where amount media was limited, ASD demonstrated complete synchronized PEO whereas found be slower incomplete from compressed ER tablets. results clearly indicated remained throughout process maintained in a supersaturated state hence kept stable with aid polymeric carrier when released manner. In addition, it robust variation hydrodynamics environment molecular weight.