Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors.
作者： Qian Zhao , Xi Xu , Zhouling Xie , Xiao Liu , Qidong You
DOI: 10.1016/J.BMCL.2015.12.014
关键词:
摘要: A new series of indenoisoquinoline derivatives was designed and synthesized. The in vitro anti-proliferative activity these novel compounds evaluated HepG2, A549 HCT-116 cell lines. Compounds 9a, 9b, 10a, 10c, 10e, 18a 18b manifested potent inhibitory against the three tested cancer Nineteen were also for Top I inhibition at 50 μM. Almost all showed this concentration. most 9a 10a demonstrated more cytotoxicity than HCPT TPT comparable to CPT activities on our biological assay.
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