DNA Topoisomerase I Inhibitors: Chemistry, Biology and Interfacial Inhibition
作者： Yves Pommier
DOI: 10.1021/CR900097C
关键词: DNA polymerase I 、 Chemistry 、 DNA clamp 、 DNA polymerase II 、 DNA supercoil 、 Biochemistry 、 Topoisomerase-I Inhibitor 、 DNA replication 、 DNA ligase 、 Topoisomerase
摘要: DNA topoisomerases I and II (Top1 and Top2) are established molecular targets of anticancer drugs. 1-5 Mammalian somatic cells express six topoisomerase genes: two TOP1 (TOP1 …
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