No Protective Function Found in Wistar Rats Submitted to Long Ischemia Time and Reperfusion After Intermittent Clamping of the Total Hepatic Pedicle
作者： R.D.R. Tártaro , G.D.L. Jorge , M.I. Leonardi , C.A.F. Escanhoela , L.S. Leonardi
DOI: 10.1016/J.TRANSPROCEED.2015.03.013
关键词:
摘要: Abstract Background Although the intermittent Pringle maneuver is used for major transplant surgery, traumas, and hepatic protection, long ischemia time reperfusion may limit some protection in Wistar rats. The aim of study was to evaluate effects clamping total pedicle after a period Methods Forty-two male rats, weighing ±327.7 g, were anesthetized intravenously with sodium thiopental given U-shaped incision abdomen. isolated subjected microvascular clamp. Groups included continuous group (CG, n = 14, 40 minutes ischemia/40 reperfusion); (IG, 4 cycles 10 minute ischemia/reperfusion minutes); sham (SG, 80 observation time). Blood collection transaminase dosage carried out, biopsy specimens taken mitochondrial respiration histological evaluation. Results In groups CG IG, aspartate aminotransferase alanine enzymes elevated comparison SG (P Conclusions rats had no efficacy liver injury.
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