Venom-derived peptide inhibitors of voltage-gated potassium channels.
作者： Raymond S. Norton , K. George Chandy
DOI: 10.1016/J.NEUROPHARM.2017.07.002
关键词:
摘要: Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations these or autoimmune attack on the channels. are also target of broad range peptide toxins venomous organisms, including sea anemones, scorpions, spiders, snakes cone snails; many peptides bind to with high potency selectivity. In this review we describe various classes block illustrate three-dimensional structures support channel blockade. The therapeutic opportunities afforded by highlighted. This article is part Special Issue entitled 'Venom-derived Peptides as Pharmacological Tools.'
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