Binding of complement component C3b to glycoprotein C is modulated by sialic acid on herpes simplex virus type 1-infected cells.

摘要: Neuraminidase treatment of cells infected with herpes simplex virus type 1 (HSV-1) markedly enhanced the binding complement component C3b to HSV glycoprotein C (gC). When HSV-1 was grown in BHK RicR14 which glycoproteins had reduced amounts N-linked complex oligosaccharides, including sialic acid, gC enhanced. We used neuraminidase demonstrate that cloning gene from F strain into an mutant fails express converted receptor negative positive. These results further support a role for as and indicate acid modifies activity. Images