Role of Complement in HIV and SIV Pathogenesis and Immunity

摘要: The complement system is comprised of a group proteins and receptors that mediate inflammation play an important role in phagocytosis lysis microorganisms (Muller-Eberhard 1988). To defend against virus infection, activated fragments component C3 (i.e., C3b, C3dg, C3d) become deposited on the surface, which then target for clearance through mononuclear phagocytic (Frank Fries 1991). Alternatively, activation may lead to assembly membrane attack complex (MAC) causing neutralization by (Hirsch 1982). Complement be directly surface epitopes impair ability factor H negatively control amplification alternative pathway C3b,Bb convertase (Fearon 1978; Pangburn et al. 1980). This type can blocked sialylation carbohydrate moieties found 1978). also Fc region antibodies bound (Schumaker 1976).