Fused heterocycles. 8 . An efficient procedure for the stereoselective synthesis of trans-2,3,3a,4-tetrahydro-3-aryl-2-phenyl[1]benzopyrano[4,3-c]pyrazoles and their [1]benzothiopyrano analogues†

作者: Albert Lévai

DOI: 10.1002/JHET.5570350103

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摘要: Stereoselective synthesis of trans-2,3,3a,4-tetrahydro-3-aryl-2-phenyl[1]benzopyrano[4,3-c]pyrazoles 13–18 and their [1]benzothiopyrano analogues 19–24 has been performed by the reaction 3-arylidenechromanones 1–6 3-arylidene-1-thiochromanones 7–12 with phenylhydrazine in hot pyridine. The structure stereochemistry compounds prepared have elucidated ir, lH 13C nmr measurements.

参考文章(8)
Tamás Lóránd, Dezső Szabó, András Földesi, László Párkányi, Alajos Kálmán, András Neszmélyi, Synthesis and stereochemistry of substituted bi- and tri-cyclic 4,5-dihydropyrazoles Journal of The Chemical Society-perkin Transactions 1. ,vol. 16, pp. 481- 486 ,(1985) , 10.1039/P19850000481
Gábor Tóth, Áron Szöllösy, Tamás Lóránd, Tibor Kónya, Dezsö Szabó, András Földesi, Albert Lévai, Fused heterocycles. Part 3. Synthesis and stereochemistry of benzopyrano and benzothiapyrano-[4,3-c]pyrazoles Journal of The Chemical Society-perkin Transactions 1. pp. 319- 323 ,(1989) , 10.1039/P29890000319
N. R. El-Rayyes, A. Al-Jawhary, Heterocycles. Part VIII. Synthesis of new substituted benz[g]indazoles Journal of Heterocyclic Chemistry. ,vol. 23, pp. 135- 140 ,(1986) , 10.1002/JHET.5570230127
K. Ramalingam, George X. Thyvelikakath, K. Darrell Berlin, Robert W. Chesnut, Rebecca A. Brown, Norman N. Durham, Steven E. Ealick, Dick Van der Helm, Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one Journal of Medicinal Chemistry. ,vol. 20, pp. 847- 850 ,(1977) , 10.1021/JM00216A024
Joseph G. Lombardino, Ivan G. Otterness, Novel immunosuppressive agents. Potent immunological activity of some bensothiopyrano [4,3-c]pyrazol-3-ones. Journal of Medicinal Chemistry. ,vol. 24, pp. 830- 834 ,(1981) , 10.1021/JM00139A012
T. L�r�nd, F. Aradi, �. Sz�ll�sy, G. T�th, T. K�nya, Isomerization of substituted tricyclic 4,5-dihydropyrazoles Monatshefte Fur Chemie. ,vol. 127, pp. 971- 977 ,(1996) , 10.1007/BF00807038