New N-Substituted (E)-4-Arylidene Isoquinoline-1,3-dione Derivatives: NMR Spectroscopic Investigation and Antibacterial Activity
作者： Nafâa Jegham , Najeh Tka , Yakdhane Kacem , Béchir Ben Hassine
DOI: 10.1080/00397911.2011.581792
关键词:
摘要: Abstract New N-substituted 4-arylidene-isoquinoline-1,3-dione derivatives were obtained as one geometrical isomer by aldol condensation of the appropriate aldehyde and corresponding homophthalimides. The structural elucidation compounds 3a–h was established infrared NMR spectroscopy including 1 H, 13 C, CH CORR, distortionless enhancement polarization transfer measurements. Compounds 3d–h evaluated for their antibacterial activity against some strains bacteria using disc diffusion method microdilution tests.
sci-hub.se 参考文章(28)
Pál Sohár, Nuclear magnetic resonance spectroscopy CRC Press. ,(1983)
S. Holly, P. Sohár, L. Láng, Absorption spectra in the infrared region Butterworths. ,(1974)
I. W. Elliott, Y. Takekoshi, Reduction of 4-arylidene-1,3-(2H,4H)isoquinolinediones Journal of Heterocyclic Chemistry. ,vol. 13, pp. 597- 599 ,(1976) , 10.1002/JHET.5570130335
D. E. Horning, G. Lacasse, J. M. Muchowski, Spiroalkylation of some Homophthalimides and Oxindoles with 1-Bromo-2-chloroethane Canadian Journal of Chemistry. ,vol. 49, pp. 246- 254 ,(1971) , 10.1139/V71-043
Norman S. Bhacca, Dudley H. Williams, Solvent effects in N.M.R. spectroscopy. I. Chemical shifts induced by benzene in some steroidal ketones and acetates Tetrahedron Letters. ,vol. 5, pp. 3127- 3132 ,(1964) , 10.1016/S0040-4039(01)89433-8
Yakdhane Kacem, Jamil Kraiem, Emna Kerkeni, Abderrahman Bouraoui, Béchir Ben Hassine, Synthesis and pharmacological profile of 6-methyl-3-isopropyl-2H-1,2-benzothiazin-4(3H)-one 1,1-dioxide derivatives: non-steroidal anti-inflammatory agents with reduced ulcerogenic effects in the rat European Journal of Pharmaceutical Sciences. ,vol. 16, pp. 221- 228 ,(2002) , 10.1016/S0928-0987(02)00046-5
Gábor Tóth, Áron Szöllősy, Albert Lévai, George Kotovych, Synthesis and stereochemistry of spiropyrazolines Journal of The Chemical Society-perkin Transactions 1. pp. 1895- 1898 ,(1986) , 10.1039/P29860001895
Geoffrey Bodenhausen, Richard R. Ernst, Alexander Wokaun, Alfred G. Redfield, Principles of nuclear magnetic resonance in one and two dimensions ,(1987)
N. R. El-Rayyes, N. H. Bahtiti, Heterocycles. Part XVII. Synthesis of new substituted 2,3,3a,4,5,6‐hexahydrobenzo[6,7]cyclohepta[1,2‐c]pyrazoles and related compounds Journal of Heterocyclic Chemistry. ,vol. 26, pp. 209- 214 ,(1989) , 10.1002/JHET.5570260137
Albert Lévai, Fused heterocycles. 8 . An efficient procedure for the stereoselective synthesis of trans-2,3,3a,4-tetrahydro-3-aryl-2-phenyl[1]benzopyrano[4,3-c]pyrazoles and their [1]benzothiopyrano analogues† Journal of Heterocyclic Chemistry. ,vol. 35, pp. 13- 16 ,(1998) , 10.1002/JHET.5570350103