Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.
作者： Matthew R. Livesey , Dario Magnani , Giles E. Hardingham , Siddharthan Chandran , David J. A. Wyllie
DOI: 10.1113/JP270660
关键词:
摘要: The in vitro derivation of regionally defined human neuron types from patient-derived stem cells is now established as a resource to investigate development and disease. Characterization such neurons initially focused on the expression developmentally regulated transcription factors neural markers, conjunction with protocols direct chart fate differentiated neurons. However, crucial understanding exploitation this technology determine degree which recapitulate key functional features exhibited by their native counterparts, essential for determining usefulness modelling physiology disease vitro. Here, we review emerging data concerning properties pluripotent cell-derived excitatory cortical neurons, context both maturation regional specificity.
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