Effects of Type II diabetes on muscle microvascular oxygen pressures
作者： Danielle J. Padilla , Paul McDonough , Brad J. Behnke , Yutaka Kano , K. Sue Hageman
DOI: 10.1016/J.RESP.2006.08.008
关键词:
摘要: We tested the hypothesis that muscle microvascular O2 pressure (PmvO2; reflecting delivery (QO2) to uptake (VO2) ratio) would be lowered in spinotrapezius of Goto-Kakizaki (GK) Type II diabetic rats (n=7) at rest and during twitch contractions when compared control (CON; n=5) rats. At rest, PmvO2 was lower GK versus CON (CON: 29+/-2; GK: 18+/-2Torr; P<0.05). onset contractions, evidenced a faster change than (i.e., time constant (tau); CON: 16+/-4; 6+/-2s; In contrast monoexponential fall steady-state level seen CON, exhibited biphasic response included blunted (or non-existent) decrease followed by recovery at, or slightly above, resting values. Compared with this decreased across transition higher metabolic rate diabetes expected impair blood-muscle exchange contractile function.
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